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Medications in Development for Treatment of Lower Functional Gastrointestinal Disorders
| New generation serotonergic agents |
| For IBS-D: ramosetron, LX-1031 |
| For IBS-C: new generation 5-HT4 agonists |
| Secretagogues: guanylate cyclase C agonists: linaclotide, plecanatide |
| Bile acid modulation: IBAT inhibitor, A3309 |
| Peripheral analgesic: asimadoline, pregabalin, GLP1 |
| Central visceral analgesic: NMDA antagonist |
| Anti-inflammatory: 5-ASA, mast cell stabilizers |
