Figure 3. Rapamycin prevents reduction in cartilage cellularity during experimental OA.
A, Knee joint sections from C57Bl/6J mice with or without OA surgery under treatment with rapamycin (rapa) or vehicle (n=6 each) were stained with Hematoxylin Eosin (H&E). Magnification: 10× and 40×. B, Quantitative analysis of cell number showed a significant increase of cellularity after rapa treatment compared to vehicle treatment. Values are the mean ± SD. * = P < 0.001 versus OA-vehicle.