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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Dec 1;52(3):638–649. doi: 10.1016/j.yjmcc.2011.11.011

Figure 5. Hearts of aging SENP2-Tg mice were hypertrophic and fibrotic.

Figure 5

A–C. SENP2-Tg mice exhibited smaller cardiomyocyte size compared with WT mice at embryonic stages. Representative WGA-TRITC staining of E14.5 heart sections (A–B) and statistical analysis (C) are shown. Surface areas were measured in 10–20 randomly selected fields from each individual heart sample (n=5 per group for WT and SENP2-Tg mice) using Software ImageJ (National Institutes of Health). Bar, 500 μm. *, p<0.05. The average surface area calculated for WT cardiomyocytes was taken as 100%. Magnification, 40×. D–F. SENP2-Tg mice developed cardiac hypertrophy with aging. Sections of hearts from mice with over one year of age were WGA-TRITC stained and the surface areas were measured as described above (n=4 per group for WT and SENP2-Tg mice). Representative data are shown in D–E and statistical analysis is shown in F. Bar, 200 μm. **, p<0.001. Magnification, 20×. G–H. Aging SENP2-Tg mouse heart presented fibrosis (Masson's trichrome staining). Bar, 200 μm. Magnification, 20×.