Table 1.

Cardiac functional analysis of WT and SENP2-Tg mice at ages of three and twelve months

Age	Three months		Twelve Months
Genotype	WT	SENP2-Tg	WT	SENP2-Tg
	n=5	n=4	n=6	n=4
LVPW; d (mm)	1.20 ± 0.08	0.803 ± 0.06**	1.28 ± 0.20	1.33 ± 0.22
Volume; s (μl)	21.83 ± 7.14	16.92 ± 1.10	16.41 ± 5.11	22.95 ± 7.08
Volume; d (μl)	63.52 ± 9.25	52.69 ± 2.98	52.41 ± 9.98	50.95 ± 11.18
stroke volume (μl)	41.69 ± 5.08	35.77 ± 2.93	36.00 ± 4.94	28.01 ± 4.10
%EF	68.51 ± 7.12	67.65 ± 2.36	71.90 ± 3.75	57.90 ± 4.74+
%FS	39.00 ± 5.37	37.02 ± 1.96	40.76 ± 3.11	29.97 ± 3.05+
cardiac output (ml/min)	14.69 ± 1.93	14.66 ± 2.88	17.35 ± 2.32	11.44 ± 1.49
LV mass (mg)	127.37 ± 10.38	97.73 ± 9.61	117.84 ± 17.49	132.77 ± 8.79
BW (g)	35.56 ± 1.92	19.80 ± 1.11**	41.58 ± 3.04	29.30 ± 1.84+
LV mass/BW	3.60 ± 0.27	4.91 ± 0.28*	2.87 ± 0.38	4.56 ± 0.32+

Cardiac functions of WT and SENP2 mice at indicated ages were analyzed by Vevo 770 as detailed in Materials and Methods. The total animal number (n) of each genotype group analyzed was shown. The unpaired Student's t test was used for statistical significance determination between groups of the same age.

^*p<0.05

^**p<0.01, compared with the WT group at three months age.

⁺p<0.05, compared with the WT group at twelve months age.

EF, left ventricular ejection faction; FS, left ventricular fractional shortening. Note that the thinner LVPW in diastole in SENP2-Tg mice measured at age of three months was completely recovered in SENP2-Tg mice at the age of twelve months, and the compromised contractility indicated by reduced %EF and %FS was present only in SENP2-Tg mice at twelve months age.