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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Toxicol In Vitro. 2011 Dec 30;26(3):485–492. doi: 10.1016/j.tiv.2011.12.014

Figure 11. Notch pathway activation in neurons disrupts nerve outgrowth in embryos that is not induced with E(spl)mδ overexpression.

Figure 11

A-C) Embryos driving expression of the Notch intracellular domain (NICD), the active component of the Notch receptor, under control of elav show notch immunoreactivity in neurons. D-F) elav> NICD embryos stained for FasII (D) and elav (E) demonstrate stunted outgrowth of the ISN (arrow head). G-I) Embryos with targeted expression of the E(spl)mδ gene in neurons stained for FasII (G) and elav (H) show normal ISN outgrowth morphology.