Table 2.

Diastolic Echocardiogram parameters

	WT	PGC-1α−/−	Ob/Ob	Ob/Ob-PGC1α−/−
HR (slow)	426 ± 12	418 ± 7	421 ± 7	407 ± 6
E	0.809 ± 0.02	0.761 ± 0.03	0.959 ± 0.05*†	0.921 ± 0.03*†
A	0.745 ± 0.02	0.745 ± 0.03	0.919 ± 0.04*†	0.894 ± 0.03*†
E/A	1.09 ± 0.04	1.02 ± 0.01	1.04 ± 0.01	1.03 ± 0.01
E′	0.050 ± 0.002	0.049 ± 0.002	0.046 ± 0.002	0.048 ± 0.001
S′	0.045 ± 0.002	0.044 ± 0.001	0.041 ± 0.002	0.040 ± 0.001
E/E′	16.4 ± 0.6	15.5 ± 0.6	21.1 ± 1.0*†	19.2 ± 0.4*†
IVCT	9.0 ± 0.3	9.4 ± 0.5	7.9 ± 0.1*†	8.6 ± 0.3*†
ET	36.1 ± 0.8	34.2 ± 1.3	38.8 ± 1.7	35.8 ± 1.4
IVRT	13.5 ± 0.4	12.5 ± 0.4	12.3 ± 0.5	13.4 ± 0.4

HR (slow) = heart rate after Zatabradine, E = Peak trans-mitral E velocity (mm/sec), A = Peak trans-mitral A velocity (mm/sec), S′ = peak systolic mitral annular velocity (mm/sec), E′ = peak early diastolic mitral annular velocity (mm/sec), A′ = peak late (atrial) mitral annular velocity (mm/sec), IVCT = isovolumic contraction time (msec), ET = ejection time (msec), IVRT = isovolumic relaxation time (msec). p < 0.05 vs WT,

^†p < 0.05 vs PGC-1α^−/−,

^¥p < 0.05 vs Ob/Ob.