Table 2.
WT | PGC-1α−/− | Ob/Ob | Ob/Ob-PGC1α−/− | |
---|---|---|---|---|
HR (slow) | 426 ± 12 | 418 ± 7 | 421 ± 7 | 407 ± 6 |
E | 0.809 ± 0.02 | 0.761 ± 0.03 | 0.959 ± 0.05*† | 0.921 ± 0.03*† |
A | 0.745 ± 0.02 | 0.745 ± 0.03 | 0.919 ± 0.04*† | 0.894 ± 0.03*† |
E/A | 1.09 ± 0.04 | 1.02 ± 0.01 | 1.04 ± 0.01 | 1.03 ± 0.01 |
E′ | 0.050 ± 0.002 | 0.049 ± 0.002 | 0.046 ± 0.002 | 0.048 ± 0.001 |
S′ | 0.045 ± 0.002 | 0.044 ± 0.001 | 0.041 ± 0.002 | 0.040 ± 0.001 |
E/E′ | 16.4 ± 0.6 | 15.5 ± 0.6 | 21.1 ± 1.0*† | 19.2 ± 0.4*† |
IVCT | 9.0 ± 0.3 | 9.4 ± 0.5 | 7.9 ± 0.1*† | 8.6 ± 0.3*† |
ET | 36.1 ± 0.8 | 34.2 ± 1.3 | 38.8 ± 1.7 | 35.8 ± 1.4 |
IVRT | 13.5 ± 0.4 | 12.5 ± 0.4 | 12.3 ± 0.5 | 13.4 ± 0.4 |
HR (slow) = heart rate after Zatabradine, E = Peak trans-mitral E velocity (mm/sec), A = Peak trans-mitral A velocity (mm/sec), S′ = peak systolic mitral annular velocity (mm/sec), E′ = peak early diastolic mitral annular velocity (mm/sec), A′ = peak late (atrial) mitral annular velocity (mm/sec), IVCT = isovolumic contraction time (msec), ET = ejection time (msec), IVRT = isovolumic relaxation time (msec). p < 0.05 vs WT,
p < 0.05 vs PGC-1α−/−,
p < 0.05 vs Ob/Ob.