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Schematic overview of a dual-hormone serotonergic perspective on human impulsive aggression. High testosterone/cortisol (T/CRT) ratio acts on the amygdala to increase reactivity of the amygdala-hypothalamus-PAG network, which facilitates a fight-response when confronted with social threat. Low 5-HT decreases prefrontal cortex (PFC) inhibitory control over the amygdala-hypothalamus-PAG network, via reduced amygdala-PFC connectivity, thereby boosting impulsive aggression
