Gene ontology (GO) analysis of subcellular localization and molecular function that were statistically up- or down- regulated in chronic pancreatitis. GO characterization using the categories listed for proteins with statistically significant differences was performed manually with the UniProt85 database or using the GoFact online tool38, 39. A) Subcellular localization and B) Molecular function of proteins down-regulated in CP (white bars), absent in CP (light grey). exclusive to CP (medium grey), up-regulated in CP (darker grey bars), and identified in both NP and CP (black bars). CP, chronic pancreatitis; NP, non-pancreatitis controls.