IQGAP1-null mice showed impaired heart function after 12 weeks of AB. (A–F) Echocardiographic parameters acquired at the indicated time points (weeks of AB) from wild type (WT) and IQGAP1-null mice (IQGAP1–/–) subjected to pressure overload. IVSd, diastolic intraventricular septum thickness; LVPWd, diastolic left ventricle posterior wall thickness; LVIDd, diastolic left ventricle inner diameter; RWT, relative wall thickness in diastole; %FS, fractional shortening. *P < 0.05 between groups (n= 10 hearts/group).