Figure 9.

IL-1–receptor blockade protects against ANCA-induced NCGN. Urine analysis and renal histologic assessment in untreated or anakinra-treated MPO^−/− mice 8 weeks after transplantation with WT bone marrow: (A) dipstick analysis, (B) albuminuria by ELISA, and (C) renal tissue analysis. Glomerular crescents and necrosis are expressed as the mean percentage of glomeruli with crescents and necrosis. Representative examples for each treatment group are depicted with ×40 magnification in (D) (untreated) and (E) (anakinra-treated) (PAS staining). (F) Infiltrating glomerular PMN and monocytes/macrophages (MoMa) as absolute number of cells per glomerulus.