Table 3.
Incidence rate of ESRD in patients with T2D during 8–12 years of follow-up according to quartiles of the distributions of baseline plasma concentrations of markers of the TNF pathway
| Quartilea | Number of Patients | Incidence Rateb | |||
|---|---|---|---|---|---|
| Free TNFα | Total TNFα | TNFR1 | TNFR2 | ||
| Q1 | 102 | 3 (3) | 0 | 0 | 0 |
| Q2 | 102 | 7 (7) | 3 (3) | 1 (1) | 2 (2) |
| Q3 | 103 | 12 (11) | 11 (11) | 5 (5) | 5(5) |
| Q4 | 101 | 49 (38) | 68 (45) | 84 (53) | 78 (52) |
| P for trendc | <10−11 | <10−12 | <10−12 | <10−12 | |
Quartile boundaries are as follows. Free TNFα (pg/ml): 3.0 for the 25th percentile, 4.3 for the 50th percentile, and 6.7 for the 75th percentile; total TNFα (pg/ml): 8.1 for the 25th percentile, 12.5 for the 50th percentile, and 17.2 for the 75th percentile; TNFR1 (pg/ml): 1049 for the 25th percentile, 1310 for the 50th percentile, and 1837 for the 75th percentile; TNFR2 (pg/ml): 2017 for the 25th percentile, 2527 for the 50th percentile, and 3363 for the 75th percentile.
Per 1000 person-years. Number of events is indicated in parentheses.
Bonferroni correction was applied.