Table A1. Timeline of illness for a patient with Lassa fever, Pennsylvania, USA, 2010.
| Test results | Jan 13–17† | 18 Jan 18‡ | Jan 19§ | Jan 20 | Jan 21 | Jan 22 | Jan 23 | Jan 24 | Jan 25 | Jan 26 | Jan 27 | Jan 28–29 | Jan 30–Feb 3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hospital laboratory testing | |||||||||||||
| Highest temperature | 101.0 °F (Jan 17) | 103.0°F | 103.3°F | 103.2°F | 101.0°F | 101.8°F | 100.4°F | 99.2°F | 101.0°F | 101.0°F | 101.0°F | Low 100s°F | Low 99s°F |
| Pulse | 99 (Jan 17) | 80s | 90s | 81–103 (EKG normal) | 100–110s | 100–110 | 98–100 | 90s | 94–114 | 91–102 | 85–110 | 84–100 | ND |
| Leukocytes | 2.7 | 3 | 4.7 | 5.5 | 5.1 | ND | ND | 6.5 (normal diff) | ND | ND | ND | ND | ND |
| Hemoglobin | 13.5 | 13.9 | 13.7 | 14 | 13.9 | ND | ND | 13.2 | ND | ND | ND | ND | ND |
| Platelets | 53 | 54 | 61 | 74 | 89 | ND | ND | 236 | ND | ND | ND | ND | ND |
| Sodium | 133 | 134 | 131 | 136 | 132 | 136 | ND | 137 | ND | ND | ND | ND | ND |
| Aspartate aminotranferase | 43 | ND | ND | 194 | 161 | 121 | ND | 191 | ND | ND | 92 | ND | ND |
| Alamine aminotransferase | 28 | ND | ND | 140 | 153 | 134 | ND | 185 | ND | ND | 161 | ND | ND |
| Alkaline phosphatase | 50 | ND | ND | 44 | ND | ND | ND | 96 | ND | ND | 95 | ND | ND |
| Total bilirubin | 0.4 | ND | ND | 0.7 | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| International normalized ratio | ND | ND | 1.1 | 1 | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| Partial thromboplastin time | ND | ND | 38.6 | 30 | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| Culture |
Blood 2× (−), Urine (−) |
Blood 2× (−), Stool (−) |
Blood 2× (−) |
Blood 2× (−), Vibrio spp. (−), Stool (−) |
Blood 2× (−) |
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| Diagnostic testing for Lassa virus | |||||||||||||
| Antigen | NA | NA | − | − | − | − | − | − | − | − | NA | − | − |
| IgG | NA | NA | − | − | − | − | − | − | − | − | NA | − | − |
| IgM | NA | NA | − | − | − | − | 400 | 1,600 | 1,600 | 6,400 | NA | 6,400 | 6,400 |
| Real-time PCR | NA | NA | + | + | + | + | + | + | + | + | NA | + | +/−¶ |
| Isolation | NA | NA | + | + | + | + | + | + | + | + | NA | + | − |
*EKG, electrocardiogram; ND, not done; NA, not available; −, negative; Ig, immunoglobulin; +, positive. †Lactate dehydrogenase 235; thick and thin blood smears for malaria negative; monoscreen negative; urine 2–5 erythrocytes, 100 protein; rapid respiratory panel negative. ‡Chest radiograph negative; HIV 1+2 antibody evaluation negative; Clostridium difficile testing negative; cryptosporidium and Giardia spp. immunoassays negative. §Chest radiograph negative; hepatitis B surface antibody negative; dengue IgG enzyme immunoassay negative; IgM enzyme immunoassay negative. ¶Sample from January 30 was PCR positive; samples from January 31 and February 1 were PCR negative.