Table 1.
Comparison between AD-HIES and DIDS
| AD-HIES | DIDS | ||
|---|---|---|---|
| Infections | |||
| Sinopulmonary | Bacterial | +++ | +++ |
| Viral | + | + | |
| Fungal | +++ | + | |
| Cutaneous | Abcesses (S. aureus) | +++ | ++ |
| Viral (HPV/HSV/MCV) | − | +++ | |
| Candidiasis | ++ | ++ | |
| Atopic diseases | |||
| Newborn rash | +++ | − | |
| Eczema | +++ | +++ | |
| Asthma | − | ++ | |
| Food/airborne allergies | − | +++ | |
| Malignancies | |||
| Lymphoma | + | ++ | |
| Squamous cell carcinomas | − | ++ | |
| Non-immunological manifestations | |||
| Characteristic facial appearances | +++ | − | |
| Retained primary teeth | +++ | − | |
| Skeletal abnormality | +++ | − | |
| Vascular abnormality | +++ | − | |
| Central nervous system abnormality | +++ | + | |
| Laboratory findings | |||
| Hyper-IgE | +++ | +++ | |
| Hypo-IgM | − | +++ | |
| T cell lymphopenia | − | +++ | |
| Eosinophilia | +++ | +++ | |
| Low Th17 T cells | +++ | ++ | |
+++ with high frequency; ++ with intermediate frequency; + occasionally reported; − rarely reported.