Fig 1.
Sequence-based typing of a collection of 191 model E. coli isolates. (Left panel) Dendrogram of concatenated 7-locus MLST sequences. (Right panel) Dendrogram of full-length type 1 fimbrial adhesin gene fimH sequences, with fimH typing region (fimHTR) alleles and amino acid polymorphisms differed from the consensus structure. Cross-connecting lines link same-strain MLST and fimH haplotypes. The scales at the bottoms of dendrograms indicate phylogenetic distance expressed as percent identity at the nucleotide level. ST numbering is according to the MLST database (http://mlst.ucc.ie/mlst/dbs/Ecoli). The number of isolates associated with the specified type (in parentheses) is shown only where that number is >1. Empty circles indicate STs that include a fimH-null strain. Colors of cross-connecting lines between dendrograms correspond to the colors of the phylogenetic group origins: red, group B2 only; blue, group B1 only; orange, group A only; green, group D only; black, two or more phylogenetic groups. FimH hot spot polymorphisms are underlined. Mature FimH peptide polymorphisms encoded outside the typing region are italicized.