Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Dec;16(12):1938–1942. doi: 10.3201/eid1612.100600

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

PMC Copyright notice

Evolution of oseltamivir-sensitive H275 in pandemic (H1N1) 2009 virus to oseltamivir-resistant virus (mutation Y275) in the neuraminidase (NA) gene, South Korea. A) NA sequences of viruses from patient A, patient H, and strain A/Korea/01/2009 (H1N1) (Control) (Table 2). Viruses from these 2 patients had triplet TAC (encoding tyrosine in NA 275), indicating that these patients were infected with oseltamivir-resistant virus, in contrast to A/Korea/01/2009 (H1N1) of the oseltamivir-sensitive control showing CAC (encoding histidine) in NA 275. B) NA sequences from specimens obtained on different dates from patient E. This patient was initially infected with oseltamivir-sensitive virus with CAC in NA 275 (2009 Dec 1). Virus then showed mutation 823C (blue dominant peak) in the boxed CAC and a minor signal 823T (small red peak) in NA 275 (2009 Dec 7). In the third specimen (2009 Dec 9), only TAC in NA 275 was observed. C) Oseltamivir-sensitive virus infection (CAC in NA 275) was observed in the first 2 specimens from patient G (2009 Dec 1 and Dec 5). Mixed signals of dominant 823T (red peak) and minor 823C (blue peak) forms were seen in most recent specimen (2009 Dec 15), indicating a mixed infection with oseltamivir-resistant virus and oseltamivir-sensitive virus. Nucleotide coordinates (815 and 831) refer to NA gene sequence of pandemic (H1N1) 2009 virus. Amino acid residue 275 in the NA gene is encoded by 3 nt indicated in boxes.