Table 2. Amino acid differences in HA and NA of viruses from 10 patients infected with oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korean, 2009*.
| Strain or patient | Sample† | Amino acid sequences |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NA |
M2 |
HA |
||||||||||||||||||
| 275 | 117 | 31 | 22 | 56 | 83 | 116 | 119 | 120 | 128 | 134 | 155 | 197 | 203 | 249 | 283 | 321 | ||||
| Kor/01ठ|
|
H
|
I
|
|
N |
|
K |
N |
S |
S |
I |
T |
S |
A |
G |
A |
S
|
V |
K |
V |
| A‡ |
1 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
S |
A |
G |
T
|
T |
V |
K |
V |
| B |
1 |
Y |
I |
|
N |
|
K |
N |
S |
N
|
I
|
I
|
S |
A |
G |
A |
T |
V |
K |
V |
| C‡ | 1 | Y | I | N | K | N | S | S | I | T | S | A | G | A | T | V | K | V | ||
|
|
2 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
S |
A |
G |
A |
T |
V |
K |
V |
| D | 1 | H | I | N | K | N | S | S | I | T | P | A | G | A | T | M | K | V | ||
|
|
2 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
P
|
A |
G |
A |
T |
M
|
K |
V |
| E | 1 | H | I | N | K | N | S | S | I | T | S | A | G | A | T | L | K | V | ||
| 2 | H | I | N | K | N | S | S | I | T | S | A | G | A | T | L | K | V | |||
|
|
3 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
S |
A |
G |
A |
T |
L
|
K |
V |
| F |
1 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
S |
T
|
G |
A |
T |
V |
K |
V |
| G | 1 | H | M | N | R | N | S | S | I | T | P | A | G | A | T | V | K | V | ||
| 2 | H | M | N | R | N | S | S | I | T | P | A | G | A | T | V | K | V | |||
|
|
3 |
Y |
M
|
|
N |
|
R
|
S
|
S |
S |
I |
T |
P
|
A |
E
|
A |
T |
V |
K |
V |
| H |
1 |
Y |
I |
|
N |
|
K |
N |
S |
S |
M
|
T |
S |
A |
G |
A |
T |
V |
K |
V |
| I |
1 |
Y |
I |
|
N |
|
K |
N |
S |
S |
I |
T |
S |
A |
G |
A |
T |
V |
E
|
V |
| J¶ |
1 |
Y |
I |
|
– |
|
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
| Cal/07# |
|
H
|
I |
|
N |
|
K |
N |
P
|
S |
I |
T |
S |
A |
G |
T
|
S
|
V |
K |
I
|
| Cal/04** | H | I | N | K | N | P | S | I | T | S | A | G | A | S | V | K | I | |||
*HA, hemagglutinin; NA, neuraminidase; M, matrix. Gene sequences for 16 clinical specimens from 10 patients were submitted to GenBank (accession nos. CY060453–CY060498). Amino acids that differ are shown in boldface. NA sequence numbering uses N1 nomenclature. †Matches the temporal order shown in the Figure. ‡Viral isolation and phenotyping of oseltamivir resistance were performed. §Pandemic A (H1N1) virus from South Korea (GenBank accession nos. GQ132185, GQ131025, and GQ131023). ¶Specimen from patient J was viral RNA. –, not available. #A/California/07/2009 virus (GenBank accession nos. GQ377078, FJ969537, and FJ969540). **A/California/04/2009 virus (GenBank accession nos. FJ969517, FJ969513, and GQ280797).