Table 3.

GMC of IgG and GMT of SBA by genotype for TLR3 and CD44 gene SNPs in the initial genetic study^a

Gene and SNP_genotypeb	IgG GMC	95% CI	No. of individuals with genotype	P valuec	SBA GMT	95% CI	No. of individuals with genotype	P valuec
TLR3
rs5743312_11	2.24	1.94–2.59	653	ref	244.78	201.48–297.37	634
rs5743312_12	1.60	1.27–2.02	223	0.02	172.75	123.24–242.15	215	0.08
rs5743312_22	1.06	0.52–2.15	21	0.07	415.87	193.14–895.46	20	0.35
rs3775291_11	1.87	1.57–2.23	425	ref	201.38	157.6–257.32	413	ref
rs3775291_12	2.20	1.83–2.64	395	0.21	242.37	189.34–310.25	380	0.30
rs3775291_22	2.06	1.33–3.2	76	0.67	325.53	186.37–568.6	75	0.13
rs3775292_11	2.09	1.79–2.44	565	ref	231.53	188.19–284.85	545	ref
rs3775292_12	2.00	1.63–2.44	303	0.74	234.27	175.72–312.33	297	0.95
rs3775292_22	1.33	0.60–2.94	29	0.21	112.58	39.79–318.53	27	0.14
rs7657186_11	1.98	1.69–2.32	551	ref	236.17	192.31–290.03	533	ref
rs7657186_12	2.23	1.83–2.71	315	0.37	233.15	174.12–312.19	304	0.94
rs7657186_22	1.11	0.53–2.33	30	0.10	95.71	35.69–256.66	31	0.04
CD44
rs353644_11	2.14	1.68–2.72	230	ref	264.19	191.13–365.19	220	ref
rs353644_12	1.84	1.55–2.19	451	0.13	189.99	150.37–240.06	437	0.11
rs353644_22	2.32	1.82–2.96	215	0.63	288.14	205.06–404.88	211	0.72
rs11033013_11	1.86	1.57–2.21	488	ref	221.94	177.79–277.06	471	ref
rs11033013_12	2.11	1.74–2.54	339	0.35	218.9	166.87–287.13	332	0.94
rs11033013_22	3.10	2.04–4.72	69	0.04	313.5	163.27–601.97	65	0.29
rs996076_11	1.68	1.31–2.14	246	ref	234.08	170.77–320.85	240	ref
rs996076_12	2.40	2.00–2.87	440	0.03	250.58	196.97–318.79	421	0.12
rs996076_22	1.76	1.42–2.19	211	0.76	180.42	129.22–251.89	208	0.26
rs12419062_11	2.37	1.68–2.35	378		245.99	190.9–316.90	365
rs12419062_12	1.93	1.61–2.31	411	0.66	202.84	158.38–259.77	402	0.29
rs12419062_22	0.38	0.23–0.52	107	0.45	272.31	168.12–441.08	101	0.71

^aThe samples were analyzed using Student's t test with the geometric mean concentration or geometric mean titer as a continuous variable, without adjustment.

^b11, wild-type homozygous genotype; 12, heterozygous genotype; 22, variant homozygous genotype.

^cref, referent/baseline group.