Fig 3.
Anti-hFcγRI-PspA reduces bacterial burden (CFU) in hFcγRI Tg mice. C57BL/6 WT and Tg mice were immunized i.n. with 25 μg of anti-hFcγRI-PspA or PBS (day 0) and then boosted twice on days 14 and 28. On day 42 mice were challenged i.n. with S. pneumoniae bacteria (1 × 106 CFU). On days 2, 4, and 7 postinfection the lung, liver, and spleen of WT and Tg mice were harvested, and bacterial burden was measured by plating on blood agar plates, as described in Materials and Methods (*, P < 0.1; **, P < 0.05).