Fig 3.

Time-response studies demonstrating that FTI acts primarily through inhibition of protein synthesis. The inhibitory effects of FTI and the component weights of fosfomycin and tobramycin on protein (a) and cell wall biosynthesis (b) in P. aeruginosa ATCC 27853 grown in CAMHB supplemented with 2 g/liter of PGM. FTI, 8 μg/ml (closed circles); tobramycin, 1.6 μg/ml (closed triangles); and fosfomycin, 6.4 μg/ml (closed squares). Values represent the means ± standard deviations (SD) from four independent experiments.