Table 2.
Phenotypic and genotypic characterization of MBLs in carbapenem-resistant isolates and isolates with decreased susceptibility
| Organism(s) | Center | MIC (μg/ml)a |
EDTA inhibition | cfiA gene | |||
|---|---|---|---|---|---|---|---|
| ERT | IMI | IMI+EDTA | DOR | ||||
| B. fragilis | 2 | >64 | >64 | ≤0.015 | >64 | + | + |
| 1 | >64 | 32 | 0.125 | >64 | + | + | |
| 1 | 32 | 32 | 0.06 | 32 | + | + | |
| 1 | 8 | 4 | ≤0.015 | 4 | + | − | |
| 3 | 8 | 0.5 | 0.125 | 4 | − | + | |
| 1 | 4 | 2 | ≤0.015 | 2 | + | − | |
| 1 | 4 | 1 | 0.125 | 4 | + | + | |
| 1 | 4 | 1 | 0.125 | 4 | + | + | |
| 2 | 4 | 0.5 | 0.125 | 4 | − | + | |
| 1 | 4 | 0.5 | 0.125 | 1 | − | − | |
| 2 | 4 | 0.5 | 0.125 | 1 | − | − | |
| 5 | 4 | 0.25 | 0.03 | 8 | + | + | |
| 6 | 4 | 0.06 | ≤0.015 | 4 | − | − | |
| 8 | 4 | 0.25 | 0.03 | 2 | + | − | |
| B. caccae | 1 | 8 | 2 | 0.125 | 8 | + | − |
| 4 | 4 | 0.5 | 0.125 | 1 | − | − | |
| 3 | 4 | 0.5 | ≤0.015 | 0.5 | + | − | |
| B. thetaiotaomicron/ovatus | 3 | >64 | 16 | 8 | 64 | − | − |
| 4 | 32 | 4 | 0.5 | 16 | + | − | |
| 1 | 8 | 2 | 0.5 | 4 | − | − | |
| 1 | 8 | 1 | ≤0.015 | 4 | + | − | |
| 7 | 4 | 0.5 | ≤0.015 | 1 | + | − | |
| B. stercoris | 1 | 16 | 4 | ≤0.015 | 4 | + | − |
a
ERT, ertapenem; IMI, imipenem; DOR, doripenem.