Fig 3.

In vivo efficacy of benzothiazole cyanine compounds against Leishmania donovani. (A) Initial evaluation of 123859 and 16196319. (B) Dose-response study with 123859. Results are presented as the percent reduction in liver parasitemia versus the untreated control; all compounds were given by the i.p. route unless otherwise indicated. p.o., oral administration. Horizontal lines and error bars denote the means and standard deviations, respectively, of the results determined with experimental groups containing four animals. *, P < 0.05 compared to untreated control; #, P < 0.05 compared to vehicle control.