Table 1.
Antileishmanial potency and cytotoxicity of selected Pubchem compounds
| Pubchem compound | IC50 (μM) for indicated targeta |
|||
|---|---|---|---|---|
| Intracellular L. donovani transgenic amastigotes | Intracellular L. amazonensis transgenic amastigotes | Peritoneal macrophages | Vero cells | |
| 3117 | 0.043 ± 0.006 | >25 | 0.27 ± 0.04 | ND |
| 5455 | 0.14 ± 0.03 | 16 ± 9b | 0.37 ± 0.036 | ND |
| 89966 | >25 | >25 | >25 | ND |
| 298107 | >25 | >25 | >25 | ND |
| 645317 | >25 | >25 | >25 | ND |
| 728862 | >25 | >25 | >25 | ND |
| 757789 | 4.7 ± 2.3 | 14 ± 1 | 9.9 ± 1.1 | 17 ± 2 |
| 760847 | 2.1 ± 1.8 | 7.8 ± 0.2 | >25 | ND |
| 786799 | >25 | >25 | >25 | ND |
| 1471937 | 1.5 ± 0.2 | 9.5 ± 3.6 | 3.3 ± 0.5 | 3.5 ± 0.3 |
| 2194030 | 12 ± 5 | 12 ± 1 | 9.9 ± 1.2 | 3.4 ± 0.2 |
| 2846928 | 1.1 ± 0.2 | 1.2 ± 0.1 | 0.39 ± 0.02 | 3.4 ± 0.6 |
| 2851545 | 11 ± 3 | >25 | >25 | ND |
| 2855568 | >25 | >25 | >25 | ND |
| 2923184 | >25 | 15 ± 0 | >25 | ND |
| 2946668 | >25 | >25 | >25 | ND |
| 2964134 | >25 | >25 | >25 | ND |
| 2999476 | >25 | >25 | >25 | ND |
| 3236501 | >25 | >25 | >25 | ND |
| 3242548 | >25 | >25 | >25 | ND |
| 3769434 | 5.3 ± 1.1 | 20 ± 6 | >25 | ND |
| 6261459 | 0.53 ± 0.19 | 0.99 ± 0.27 | >25 | ND |
| 6603247 | 3.5 ± 2.0 | >25 | >25 | ND |
| 6604199 | 0.38 ± 0.22 | >25 | 2.6 ± 0.5 | 0.12 ± 0.03b |
| 9549148 | >25 | >25 | >25 | ND |
| 11293258 | 1.1 ± 0.1 | 1.0 ± 0.3 | 0.82 ± 0.14 | 5.0 ± 1.0 |
| 15945170 | 20 ± 6 | >25 | >25 | ND |
| 16196001 | 3.6 ± 1.4 | 7.8 ± 1.1 | >25 | ND |
| 16196223 | 0.18 ± 0.05 | 0.20 ± 0.04 | 4.1 ± 0.6 | 2.0 ± 0.1 |
| 16196319 | 0.26 ± 0.09 | 0.64 ± 0.32 | 5.2 ± 0.3 | ND |
| AmB | 0.046 ± 0.016 | 0.097 ± 0.012 | ND | ND |
| Podophyllotoxin | ND | ND | ND | 0.016 ± 0.001 |
a
Data represent means ± standard errors of the results of at least three independent determinations unless noted otherwise. ND, not determined.
b
Values represent the mean ± range of the results of two independent determinations.