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Dose-dependent inhibition of the HCV replicon by MK-4519 in BelloCell dose-ranging studies. Luciferase activity (A) and HCV RNA relative to GAPDH RNA (B) of 2209-23 cells at various times after MK-4519 exposure. BelloCell bottles were inoculated with 6 × 107 replicon-bearing 2209-23 cells and continuously infused with 0, 6, 10, or 30 nM MK-4519. Data points indicate median values of three independent samples, and error bars correspond to 1 standard deviation.
