Table 2.

Confirmed lead compound structures inhibiting EtCatB^a

^aThree confirmed lead compounds against EtCatB were identified, belonging to the structural classes nitrile, thiosemicarbazone, and oxazolone. Cathepsin B from bovine spleen (BtCatB) was used as the counter-assay to test the selectivity profile of the confirmed leads. Results are expressed as mean IC₅₀ ± standard deviation from three independent experiments and as graphically determined K_i values ± standard deviation from four independent experiments.

^bND, not determined.