Table 1.
Antimicrobial activity of oritavancin against vancomycin-susceptible and vancomycin-resistant enterococcal clinical isolates causing bloodstream infections in U.S. and European hospitals
| Organism and resistance (no. tested) | MIC (μg/ml) |
Numbera (cumulative %) inhibited at MIC (μg/ml) ofa: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 50% | 90% | ≤0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | |
| E. faecalis (1,312) | |||||||||
| Vancomycin susceptible (1,275) | 0.015 | 0.03 | 435 (34.1) | 575 (79.2) | 211 (95.8) | 43 (99.1) | 7 (99.7) | 3 (99.9) | 1 (100.0) |
| vanA (27) | 0.25 | 0.5 | 0 (0.0) | 1 (3.7) | 3 (14.8) | 3 (25.9) | 0 (25.9) | 15 (81.5) | 5 (100.0) |
| vanB (10) | 0.015 | 0.015 | 1 (10.0) | 8 (90.0) | 0 (90.0) | 1 (100.0) | − | − | − |
| E. faecium (869) | |||||||||
| Vancomycin susceptible (383) | ≤0.008 | ≤0.008 | 374 (97.7) | 7 (99.5) | 2 (100.0) | − | − | − | − |
| vanA (470) | 0.03 | 0.06 | 76 (16.2) | 74 (31.9) | 146 (63.0) | 133 (91.3) | 37 (99.1) | 4 (100.0) | − |
| vanB (16) | ≤0.008 | ≤0.008 | 16 (100.0) | − | − | − | − | − | − |
| E. casseliflavus (15) and E. gallinarum (24) | |||||||||
| vanC (39) | ≤0.008 | 0.015 | 34 (87.2) | 5 (100.0) | − | − | − | − | − |
a
Modal MICs are in bold.