Table 2.
Antimicrobial activity of oritavancin and comparator agents against vancomycin-susceptible and vancomycin-resistant enterococcal clinical isolates causing bloodstream infections in U.S. and European hospitals
| Organism (no. tested) and antimicrobial agent | MIC (μg/ml) |
% Susceptible/% resistanta |
|||
|---|---|---|---|---|---|
| Range | 50% | 90% | CLSI | EUCAST | |
| Vancomycin-susceptible E. faecalis (1,275) | |||||
| Oritavancin | ≤0.008–0.5 | 0.015 | 0.03 | −/− | −/− |
| Ampicillin | ≤1–8 | ≤1 | 2 | 100.0/0.0 | 99.8/0.0 |
| Vancomycin | 0.25–4 | 1 | 2 | 100.0/0.0 | 100.0/0.0 |
| Teicoplanin | ≤2–4 | ≤2 | ≤2 | 100.0/0.0 | 99.9/0.1 |
| Daptomycin | 0.12–4 | 1 | 2 | 100.0/− | −/− |
| Linezolid | 0.25–>8 | 1 | 2 | 99.9/0.1 | 99.9/0.1 |
| Quinupristin-dalfopristin | ≤0.5–>2 | >2 | >2 | 0.5/95.0 | 0.5/89.0 |
| Levofloxacin | ≤0.5–>4 | 1 | >4 | 69.0/30.4 | −/− |
| Tetracycline | ≤2–>8 | >8 | >8 | 23.2/76.5 | −/− |
| vanA E. faecalis (27) | |||||
| Oritavancin | 0.015–0.5 | 0.25 | 0.5 | −/− | −/− |
| Ampicillin | ≤1–>16 | ≤1 | 2 | 96.3/3.7 | 96.3/3.7 |
| Vancomycin | >16 | >16 | >16 | 0.0/100.0 | 0.0/100.0 |
| Teicoplanin | >8 | >8 | >8 | 3.7/96.3 | 0.0/100.0 |
| Daptomycin | 0.5–2 | 1 | 2 | 100.0/− | −/− |
| Linezolid | 1–2 | 1 | 1 | 100.0/0.0 | 100.0/0.0 |
| Quinupristin-dalfopristin | 2–>2 | >2 | >2 | 0.0/96.3 | 0.0/96.3 |
| Levofloxacin | 2–>4 | >4 | >4 | 3.7/96.3 | −/− |
| Tetracycline | ≤2–>8 | >8 | >8 | 3.7/96.3 | −/− |
| vanB E. faecalis (10) | |||||
| Oritavancin | ≤0.008–0.06 | 0.015 | 0.015 | −/− | −/− |
| Ampicillin | ≤1–2 | ≤1 | 2 | 100.0/0.0 | 100.0/0.0 |
| Vancomycin | 8–>16 | >16 | >16 | 0.0/80.0 | 0.0/100.0 |
| Teicoplanin | ≤2 | ≤2 | ≤2 | 100.0/0.0 | 100.0/0.0 |
| Daptomycin | ≤0.06–2 | 0.5 | 1 | 100.0/− | −/− |
| Linezolid | 0.5–2 | 1 | 1 | 100.0/0.0 | 100.0/0.0 |
| Quinupristin-dalfopristin | >2 | >2 | >2 | 0.0/100.0 | 0.0/100.0 |
| Levofloxacin | >4 | >4 | >4 | 0.0/100.0 | −/− |
| Tetracycline | ≤2–>8 | ≤2 | >8 | 50.0/50.0 | −/− |
| Vancomycin-susceptible E. faecium (383) | |||||
| Oritavancin | ≤0.008–0.03 | ≤0.008 | ≤0.008 | −/− | −/− |
| Ampicillin | ≤1–>8 | >8 | >8 | 14.4/85.6 | 14.1/85.6 |
| Vancomycin | 0.25–4 | 1 | 1 | 100.0/0.0 | 100.0/0.0 |
| Teicoplanin | ≤2–4 | ≤2 | ≤2 | 100.0/0.0 | 99.7/0.3 |
| Daptomycin | 0.12–>8 | 2 | 4 | 99.7/− | −/− |
| Linezolid | 0.5–>8 | 1 | 2 | 99.2/0.8 | 99.2/0.8 |
| Quinupristin-dalfopristin | ≤0.5–>2 | ≤0.5 | >2 | 72.1/15.7 | 72.1/11.7 |
| Levofloxacin | ≤0.5–>4 | >4 | >4 | 15.4/77.5 | −/− |
| Tetracycline | ≤2–>8 | ≤2 | >8 | 56.7/42.8 | −/− |
| vanA E. faecium (470) | |||||
| Oritavancin | ≤0.008–0.25 | 0.03 | 0.06 | −/− | −/− |
| Ampicillin | >8 | >8 | >8 | 0.0/100.0 | 0.0/100.0 |
| Vancomycin | >16 | >16 | >16 | 0.0/99.6 | 0.0/100.0 |
| Teicoplanin | ≤1–>8 | >8 | >8 | 0.6/96.2 | 0.2/99.8 |
| Daptomycin | 0.12–4 | 2 | 2 | 100.0/− | −/− |
| Linezolid | 0.5–>8 | 1 | 2 | 98.1/1.3 | 98.7/1.3 |
| Quinupristin-dalfopristin | ≤0.5–>2 | ≤0.5 | 1 | 96.6/1.3 | 96.6/1.3 |
| Levofloxacin | 2–>4 | >4 | >4 | 0.2/99.8 | −/− |
| Tetracycline | ≤2–>8 | >8 | >8 | 36.8/62.3 | −/− |
| vanB E. faecium (16) | |||||
| Oritavancin | ≤0.008 | ≤0.008 | ≤0.008 | −/− | −/− |
| Ampicillin | >8 | >8 | >8 | 0.0/100.0 | 0.0/100.0 |
| Vancomycin | 8–>16 | >16 | >16 | 0.0/75.0 | 0.0/100.0 |
| Teicoplanin | ≤2 | ≤2 | ≤2 | 100.0/0.0 | 100.0/0.0 |
| Daptomycin | 0.5–4 | 2 | 2 | 100.0/− | −/− |
| Linezolid | 0.5–4 | 1 | 2 | 93.8/0.0 | 100.0/0.0 |
| Quinupristin-dalfopristin | ≤0.5–>2 | ≤0.5 | >2 | 87.5/12.5 | 87.5/12.5 |
| Levofloxacin | >4 | >4 | >4 | 0.0/100.0 | −/− |
| Tetracycline | ≤2–>8 | >8 | >8 | 37.5/62.5 | −/− |
| vanC enterococci (39)b | |||||
| Oritavancin | ≤0.008–0.015 | ≤0.008 | 0.015 | −/− | −/− |
| Ampicillin | ≤1–>16 | ≤1 | 2 | 97.4/2.6 | 97.4/2.6 |
| Vancomycin | 0.25–8 | 4 | 8 | 82.1/0.0 | 82.1/17.9 |
| Teicoplanin | ≤2 | ≤2 | ≤2 | 100.0/0.0 | 100.0/0.0 |
| Daptomycin | ≤0.06–4 | 1 | 2 | 100.0/− | −/− |
| Linezolid | 0.5–2 | 1 | 2 | 100.0/0.0 | 100.0/0.0 |
| Quinupristin-dalfopristin | ≤0.5–>2 | 2 | >2 | 7.7/48.7 | 7.7/30.8 |
| Levofloxacin | ≤0.5–>4 | 2 | 4 | 84.6/5.1 | −/− |
| Tetracycline | ≤2–>8 | ≤2 | >8 | 74.4/25.6 | −/− |