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Activities of pyrrolamide 4 and comparators against GyrB mutant strainsa of S. aureus
| Compound |
S. aureus MIC (μg/ml) |
||
|---|---|---|---|
| Parent | GyrB R144I | GyrB T173A | |
| Pyrrolamide 4 | 8 | 32 | 64 |
| Novobiocin | 0.25 | 8 | 0.25 |
| Levofloxacin | 0.25 | 0.25 | 0.25 |
Resistant strains of S. aureus were selected on media containing pyrrolamide 4 at 8 μg/ml. Point mutations in the gyrB genes were identified and mapped to the amino acids shown by sequencing genomic DNA isolated from different resistant strains.
