Table 4.
Global tropism assay resultsa
| Parameter | Value (%) for test |
||||||
|---|---|---|---|---|---|---|---|
| G2P5%cli | G2P5%clo | G2P10%cli | G2P10%clo | PSSM | PSSMp | UDS | |
| Concordance | 81.5 | 80.0 | 80.0 | 78.5 | 73.9 | 76.9 | 81.5 |
| Sensitivity | 47.4 | 57.9 | 47.4 | 68.4 | 57.9 | 84.2 | 83.3 |
| Specificity | 95.7 | 89.1 | 93.5 | 82.6 | 80.4 | 73.9 | 77.8 |
| PPV | 81.8 | 68.8 | 75.0 | 61.9 | 55.0 | 57.1 | 88.2 |
| NPV | 81.5 | 83.7 | 81.1 | 86.4 | 82.2 | 91.9 | 70.0 |
a
PPV, positive predictive value; NPV, negative predictive value; G2P5%cli, clinical G2P test at 5%; G2P5%clo, clonal G2P test at 5%; G2P10%cli, clinical G2P test at 10%; G2P5%clo, clonal G2P test at 10%; PSSMp, PSSM test using Poveda's score; UDS, ultradeep sequencing with a cutoff of 2%.