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Number of cDNA clones encoding the indicated amino acids in NS5Aa
| Replicon | Amino acid substitution | No. of cDNA clones at indicated BMS-790052 selection concn (nM) |
|
|---|---|---|---|
| 0.1 | 1 | ||
| HCV4a-21 | R30G | 4 | 4 |
| R30H | 5 | 7 | |
| R30S | 10 | 12 | |
| R30H/Y93C | 1 | ||
| HCV4a-23 | L30H | 7 | 16 |
| L30R | 2 | ||
| L30V | 1 | ||
| M31I | 1 | ||
| M31V | 1 | ||
| P32L | 1 | ||
| P58H | 1 | ||
| Y93H | 2 | 3 | |
| Y93R | 1 | ||
| L30I/Y93R | 1 | ||
cDNA clones were isolated from HCV4a replicon cells selected for resistance to BMS-790052 at the indicated concentrations.
