Table 3.
Protection of mice from E. coli ATCC 35318 by battacin and reference compoundsa
| Drug | Single intravenous dose (mg/kg)/day for 1 day to 3 days | No. of surviving mice/total no. of mice | P value vs saline |
|---|---|---|---|
| Saline | 1/10 | ||
| Cefodizime sodium | 800 | 10/10 | <0.05 |
| Battacin | 1 | 2/10 | >0.05 |
| Battacin | 2 | 5/10 | <0.05 |
| Battacin | 4 | 9/10 | <0.05 |
a
ICR mice (n = 10 per group) were inoculated intraperitoneally with 0.5 ml of E. coli ATCC 35318 cells (3.6 × 106 CFU/ml) and treated intravenously with three doses (1, 24, and 48 h after infection) of physiological saline, battacin, or a reference compound.