Fig 3.
The resistance of emerging variants increases with increasing BMS-790052-treatment concentrations. EC50s of BMS-790052 on H77c replicon variants with the indicated amino acid substitutions are plotted. The concentrations of BMS-790052 at which variants were detected in replicon elimination assays are indicated by the bars below the plot. 1a wt, genotype 1a wild-type replicon. Values are the means ± standard deviations (n ≥ 3) from transient replicon assays, except for M28T/Y93H, which is from stable replicon cell assays since this variant did not replicate in transient assays.