Table 1.
MICs of β-lactams for E. coli MAS clinical isolate, E. coli TOJ53 strain harboring the natural blaKPC-2-positive plasmid pMAS from E. coli MAS, and E. coli J53 recipient strain
| β-Lactama | MIC for strain |
||
|---|---|---|---|
| E. coli MAS (KPC-2) | E. coli J53 (pMAS) | E. coli J53 | |
| Amoxicillin | >256 | >256 | 4 |
| Amoxicillin + CLA | 128 | 32 | 4 |
| Ticarcillin | >256 | >256 | 2 |
| Ticarcillin + CLA | 256 | >256 | 2 |
| Piperacillin | >256 | 128 | 1 |
| Piperacillin + TZB | >256 | 128 | 1 |
| Cefuroxime | >256 | 256 | 2 |
| Ceftazidime | 256 | 32 | 0.06 |
| Cefotaxime | 128 | 4 | 0.12 |
| Cefepime | 128 | 2 | 0.06 |
| Cefoxitin | 256 | 2 | 2 |
| Aztreonam | >256 | 8 | 0.06 |
| Imipenem | 8 | 2 | 0.06 |
| Meropenem | 16 | 1 | 0.03 |
| Ertapenem | 256 | 0.5 | 0.03 |
| Ciprofloxacin | >256 | 0.06 | 0.06 |
| Gentamicin | 64 | 4 | 0.12 |
| Amikacin | 64 | 4 | 0.12 |
| Fosfomycin | 0.25 | 0.06 | 0.06 |
| Tetracycline | 0.5 | 0.03 | 0.03 |
| Tigecycline | 0.25 | 0.03 | 0.03 |
| Colistin | 0.25 | 0.12 | 0.12 |
a
CLA, clavulanic acid; TZB, tazobactam (both at a concentration of 4 μg/ml).