Table 2.

Kill kinetics of TD-1792 and comparators against six S. aureus isolates

Organism	Antibiotic	MIC (μg/ml)	Concn tested (μg/ml)	Δlog10 CFU/ml at:
				2 h	4 h	8 h	24 h
MSSA ATCC 29213	TD-1792	0.015	0.03	−2.1	−3.0	−3.9	−4.3
			0.06	−0.8	−2.4	−3.9	−4.7
			0.12	−0.5	−2.4	−4.2	−3.8
	Vancomycin	1	8	−0.7	−0.9	−2.6	−4.7
	Nafcillin	0.5	4	−0.6	−1.0	−2.5	−4.6
	Cefazolin	0.5	4	0.1	−0.5	−2.4	−3.0
MSSA ATCC 13709	TD-1792	0.015	0.03	−1.9	−3.4	−4.1	−5.5
			0.06	−1.5	−2.7	−3.4	−5.4
			0.12	−1.6	−3.5	−4.6	−5.3
	Vancomycin	0.5	4	−0.2	0.0	−1.0	−5.0
	Nafcillin	1	8	−0.2	−0.1	−0.9	−5.7
	Cefazolin	0.5	4	0.2	−0.4	−2.3	−3.2
MRSA ATCC 33591	TD-1792	0.03	0.06	0.1	−0.3	−1.5	−4.2
			0.12	−0.1	−0.3	−1.4	−4.1
			0.25	−0.7	−1.2	−2.3	−3.7
	Vancomycin	1	8	0.0	0.1	−0.9	−3.2
	Linezolid	1	8	0.1	0.1	−0.8	−1.7
MRSA MED 1805	TD-1792	0.015	0.03	−0.5	−2.7	−3.2	−3.3
			0.06	−1.0	−2.6	−3.2	−4.2
			0.12	−1.9	−3.1	−3.7	−3.9
	Vancomycin	0.5	4	−0.1	−0.2	−0.9	−3.4
	Linezolid	2	16	0.0	−0.4	−0.3	−1.6
MRSA MED 2028a	TD-1792	0.03	0.06	−0.2	−3.3	−3.9	−3.7
			0.12	−0.7	−3.3	−3.8	−4.4
			0.25	−3.6	−3.7	−4.2	−4.3
	Vancomycin	1	8	0.1	−0.1	−0.7	−4.0
	Linezolid	2	16	0.0	−0.6	−1.8	−2.7
VISA Mu50	TD-1792	0.06	0.12	−0.7	−2.4	−3.3	−3.6
			0.25	−1.5	−3.2	−4.1	−4.2
			0.5	−2.3	−4.0	−4.2	−4.1
	Vancomycin	4	32	−0.2	−0.4	−0.8	−2.5
	Linezolid	2	16	−0.2	−0.3	−0.9	−2.3

^aMRSA isolate nonsusceptible to daptomycin.