Table 2.

Parameter estimates of the model describing the relationship between the AUC/MIC ratio and the efficacy for TD-1792 against MRSA ATCC 33591 in the neutropenic murine thigh model of infection^a

Parameter	Estimate	95% CI
Econ	3.25	2.87–3.63
Emax	5.12	4.23–6.00
Hill	1.83	1.12–2.54
EC50	15.6	11.3–19.9

^aE_con is the change in log₁₀ CFU/g from the baseline after 24 h when no drug is administered; E_max is the maximum change in log₁₀ CFU/g from the baseline at 24 h after administering TD-1792; the AUC/MIC ratio is the PK-PD index of interest; EC₅₀ is the value for the AUC/MIC ratio at which there is half-maximal change in log₁₀ CFU/g; and Hill is the Hill's coefficient of sigmoidicity.