Fig 2.
Sudden death in PG/β-catenin DKO mice. (A to D) Heart sections from PGflox/flox/β-cateninflox/flox; Cre− (WT) (A and B) and PGflox/flox/β-cateninflox/flox; Cre+ (DKO) (C and D) mice were immunostained for plakoglobin (PG) (A and C) and β-catenin (βcat) (B and D) 3 months after Tam administration. (E) Heart lysates from WT (n = 8) and DKO (n = 10) mice were immunoblotted for PG and β-catenin. (F) Kaplan-Meier survival curve shows completely penetrant sudden-death phenotype in the DKO mice (23/23; median survival, 105 days), compared to the survival of PG CKO mice (9/105), β-catenin CKO mice (3/76), and WT controls (3/81) within 6 months after Tam administration. ***, P < 0.001.