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Depletion of respiratory proteins from complexes I and IV does not significantly affect mitochondrial crista morphology. (A and B) NDUFS1kd-1 (pool) and CoxVakd-2 (single clone) cells were grown for 7 days in the absence (−Dox) or presence (+Dox) of doxycycline. Cells were then analyzed by TEM (lower panels), and mitochondria were isolated in parallel and analyzed by SDS-PAGE and Western blotting. Scale bar, 1 μm. For designations, see the text and the legends for Fig. 1, 3, and 4.
