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LPS exerts a greater effect on GFAP and MHCII immunoreactivity in hippocampus of aged, compared with young, rats. Treatment of young rats with LPS (100μg/kg intraperitoneally) increased GFAP and MHCII immunoreactivity in hippocampal tissue but the effect was more marked in aged rats. Age-related increases in immunoreactivity of both markers were also observed.
