Table 1.
HPV genotype distributions in women with different grades of cervical intraepithelial neoplasm (CIN)
| HPV DNA or genotype | No. (%) of infections |
|||||
|---|---|---|---|---|---|---|
| CIN1 (n = 143) |
CIN2 (n = 181) |
CIN3 (n = 276) |
||||
| Single and/or in concurrence with other HPV genotypes | Single infection | Single and/or in concurrence with other HPV genotypes | Single infection | Single and/or in concurrence with other HPV genotypes | Single genotype infection | |
| HPV DNA | 85 (59.4) | 149 (82.3) | 251 (90.9) | |||
| HR-HPV DNA | 73 (51.0) | 136 (75.1) | 246 (89.1) | |||
| HPV-16 | 23 (16.1)b | 11 (7.7) | 55 (30.4) | 35 (19.3) | 149 (54.0) | 107 (38.8) |
| HPV-58 | 20 (14.0)c | 12 (8.4) | 39 (21.5) | 25 (13.8) | 76 (26.1) | 37 (13.4) |
| HPV-52 | 24 (16.8) | 9 (6.3) | 33 (18.2) | 15 (8.3) | 22 (8.0) | 8 (2.9) |
| HPV-33 | 5 (3.5)d | 3 (2.1) | 11 (6.1) | 6 (3.3) | 31 (11.2) | 16 (5.8) |
| HPV-18 | 4 (2.8) | 2 (1.4) | 11 (6.1) | 4 (2.2) | 12 (4.3) | 3 (1.1) |
| HPV-68 | 5 (3.5) | 2 (1.4) | 3 (1.7) | 1 (0.6) | 3 (1.1) | 0 |
| HPV-53a | 7 (4.9) | 2 (1.4) | 6 (3.3) | 1 (0.6) | 4 (1.4) | 0 |
| HPV-31 | 4 (2.8) | 2 (1.4) | 12 (6.6) | 8 (4.45) | 18 (6.5) | 2 (0.7) |
| HPV-66 | 5 (3.5) | 2 (1.4) | 1 (0.6) | 0 | 1 (0.4) | 1 (0.4) |
| HPV-11a | 5 (3.5) | 3 (2.1) | 11 (6.1) | 7 (3.9) | 5 (1.8) | 2 (0.7) |
| HPV-42a | 2 (1.4) | 0 | 0 | 0 | 1 (0.4) | 0 |
| HPV-59 | 0 | 0 | 4 (2.2) | 1 (0.6) | 3 (1.1) | 1 (0.4) |
| HPV-6a | 5 (3.5) | 3 (2.1) | 4 (2.2) | 1 (0.6) | 2 (0.7) | 2 (0.7) |
| HPV-51 | 2 (1.4) | 1 (0.7) | 0 | 0 | 1 (0.4) | 0 |
| HPV-35 | 1 (0.7) | 0 | 1 (0.6) | 0 | 1 (0.4) | 0 |
| HPV-39 | 2 (1.4) | 0 | 5 (2.8) | 0 | 1 (0.4) | 0 |
| HPV-45 | 0 | 0 | 0 | 0 | 3 (1.1) | 2 (0.7) |
| HPV-81a | 6 (4.2) | 1 (0.7) | 5 (2.8) | 1 (0.6) | 1 (0.4) | 0 |
a
Low-risk types.
b
χ2 = 7.91, P < 0.001, Cochran-Armitage trend test.
c
χ2 = 2.82, P < 0.003, Cochran-Armitage trend test.
d
χ2 = 2.93, P < 0.002, Cochran-Armitage trend test.