Table 1.
S. pneumoniae serotype 6D isolates used in this study, their MLST data, and antimicrobial susceptibilities
| Serotype | STa | Isolate | Yr | Specimenb | Penicillin resistancec | Resistance profiled |
|---|---|---|---|---|---|---|
| 6A | 81 (4-4-2-4-4-1-1) | Kor 146 | 1998 | Transtracheal aspirate | I | FUR-ERY-AZI-CLA-CD |
| 420 | 1999 | ND | I | FUR-ERY-SXT | ||
| K10-25 | 2000 | Eye discharge | I | FUR-ERY-AZI-CLA | ||
| Kor 14 | 2000 | Sputum | I | FUR-ERY | ||
| K08-52 | 2008 | Sputum | R | FUR-ERY-AZI-CLA-CD | ||
| K01-39 | 2008 | CSF | R | FUR-ERY | ||
| K07-13 | 2008 | Sputum | I | FUR-SXT | ||
| K08-9 | 2008 | CSF | I | FUR | ||
| K08-12 | 2008 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-1 | 2008 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-4 | 2008 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-17 | 2008 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-50 | 2008 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K16-94 | 2008 | CSF | I | FUR-ERY-AZI-CLA-CD-SXT | ||
| K13-75 | 2009 | Sputum | R | FUR-ERY-AZI-CLA-CD | ||
| K13-59 | 2009 | Sputum | R | FUR-ERY-AZI-CLA-CD | ||
| K13-70 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-72 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-78 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-85 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD-SXT | ||
| K13-87 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K13-98 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD-SXT | ||
| K13-102 | 2009 | Sputum | S | ERY | ||
| K13-120 | 2009 | Sputum | I | ERY-AZI-CLA-CD | ||
| K13-130 | 2009 | Sputum | I | FUR-ERY-AZI-CLA-CD | ||
| K15-64 | 2009 | Sputum | I | FUR-ERY | ||
| 6D | 282 (30-4-2-4-4-1-1) | 04-8 | 2004 | Sputum | R | FUR-ERY-AZI-CLA |
| 05-246 | 2005 | Sputum | R | FUR-ERY-AZI-CLA | ||
| 05-387 | 2005 | Pus | R | FUR-ERY -CLA | ||
| 06-265 | 2006 | Sputum | I | FUR-ERY -CLA | ||
| 07-056 | 2007 | Sputum | R | FUR-ERY-AZI | ||
| 07-077 | 2007 | Sputum | R | FUR-ERY-AZI-CLA-CIP | ||
| 07-107 | 2007 | Transtracheal aspirate | I | FUR-ERY-AZI-LEV-GAT-CIP | ||
| K15-99 | 2008 | ND | I | FUR-ERY-AZI-CLA-CD-SXT | ||
| K15-129 | 2008 | ND | I | FUR-ERY-AZI-CLA | ||
| K15-115 | 2009 | ND | I | FUR-ERY-AZI-CLA-SXT | ||
| K15-17 | 2009 | Sputum | I | FUR-ERY | ||
| K13-108 | 2009 | Sputum | I | FUR-LEV-GAT-CIP | ||
| K13-109 | 2009 | Sputum | I | LEV-GAT-CIP | ||
| K13-110 | 2009 | Sputum | I | FUR-LEV-GAT-CIP | ||
| 4762 (30-4-2-4-30-1-1) | K15-60 | 2008 | Sputum | I | FUR | |
| 3595 (30-4-2-1-4-4-1) | B0704-047 | 2007 | Blood | I | FUR-ERY-AZI | |
| 3171 (8-13-9-6-78-119-14) | Kor 74 | 1997 | Throat swab | S | ERY-AZI-CLA-CD | |
| 05-447 | 2005 | Transtracheal aspirate | S | ERY-AZI-CLA-CD | ||
| K13-22 | 2009 | Sputum | S | ERY-AZI-CLA-CD |
a
aroE-gdh-gki-recP-spi-xpt-ddl.
b
ND, not described; CSF, cerebrospinal fluid.
c
MIC breakpoints of penicillin susceptibility: susceptible (S), ≤0.06 mg/liter; intermediate (I), 0.12 to 1 mg/liter; and resistant (R), ≥2 mg/liter.
d
FUR, cefuroxime; AMX, amoxicillin; A/C, amoxicillin-clavulanate; AXO, ceftriaxone; ERY, erythromycin; AZI, azithromycin; CLA, clarithromycin; CD, clindamycin; LEV, levofloxacin; MOX, moxifloxacin; GAT, gatifloxacin; CIP, ciprofloxacin; SXT, trimethoprim-sulfamethoxazole.