Table 5.
Result of univariate and multivariate multinomial regression analysis of gene presence among bovine, food, and clinical human STEC O157 isolates from The Netherlandsd
| Variable | Univariable analysisa |
Multivariable analysisa,b |
||||||
|---|---|---|---|---|---|---|---|---|
| Bovine |
Food |
Bovine |
Food |
|||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| stx1 | 0.68 (0.33–1.40) | 0.294 | 1.34 (0.54–3.29) | 0.526 | ||||
| stx2a | 0.13 (0.06–0.27) | <0.0001 | 0.33 (0.14–0.81) | 0.015 | 0.25 (0.11–0.54) | 0.001 | 0.54 (0.21–1.41) | 0.208 |
| stx2c | 5.08 (2.30–11.24) | <0.0001 | 2.02 (0.81–5.08) | 0.133 | ||||
| q21 | 3.74 (1.73–8.13) | 0.001 | 1.41 (0.57–3.47) | 0.454 | ||||
| Q933 | 0.13 (0.06–0.28) | <0.0001 | 0.41 (0.17–0.98) | 0.044 | ||||
| tir(255A) | 14.71 (5.68–37.03) | <0.0001 | 8.06 (2.63–24.39) | <0.0001 | ||||
| tir(255T) | 0.07 (0.03–0.18) | <0.0001 | 0.12 (0.04–0.38) | <0.0001 | 0.12 (0.04–0.31) | <0.0001 | 0.16 (0.05–0.53) | 0.003 |
| rhsA(3468C) | 1.21 (0.65–2.27) | 0.554 | 1.28 (0.55–3.00) | 0.570 | ||||
| rhsA(3468G) | 0.83 (0.44–1.55) | 0.554 | 0.78 (0.33–1.83) | 0.570 | ||||
| folD-sfmA | 12.35 (1.56–97.00) | 0.017 | 1.03 (0.30–3.47) | 0.003 | ||||
| Z5935 | 12.73 (5.02–32.26) | <0.0001 | 9.51 (3.50–25.83) | <0.0001 | ||||
| yhcG | 0.123 (0.09–0.32) | <0.0001 | 0.37 (0.10–1.3) | <0.0001 | ||||
| rtcB | 14.12 (3.53–6.06) | <0.0001 | 7.43 (2.49–22.18) | <0.0001 | ||||
| rbsB | NAc | NA | ||||||
| yehV-LJ | 0.30 (0.02–1.05). | 0.056 | 0.37 (0.10–1.3) | 0.120 | ||||
| yehV-RJ | 3.68 (1.91–7.09) | 0.002 | 1.69 (0.71–4.06) | 0.237 | ||||
| wrbA-LJ | 4.69 (0.53–41.06) | 0.163 | 0.39 (0.01–1.57) | 0.185 | ||||
| wrbA-RJ | 8.50 (2.43–29.73) | 0.001 | 1.34 (0.48–3.72) | 0.567 | ||||
The odds ratios (ORs) indicate whether a gene or allelic variant is more (>1) or less (<1) likely to be associated with the bovine or food isolates compared to the human isolates. (The human isolates serve as the reference in the regression analysis.) 95% CI, 95% confidence interval. The P values shown represent the P values of the ORs.
Model fit, P < 0.0001; likelihood ratio tests, stx2a, chi-square = 13.74, P = 0.002; tir(T255), chi-square = 23.39, P < 0.0001.
NA, not available. The OR could not be calculated because all human and food isolates showed the same allelic type (type 1) in the rbsB locus.
Significant values are indicated in boldface.