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Protease-triggered release of Dox in vivo: (a) Schematic for evaluating protease-triggered release from core-loaded MSNPs. (b) Immunoblots for protein levels of caspases (apoptotic markers) and GAPDH from tumor lysates of animals 60 h after treatment. (c) TUNEL staining for apoptotic cells in tumor sections. Red, TUNEL; blue, DAPI. Scale is 50 μm.
