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. Author manuscript; available in PMC: 2012 Mar 6.
Published in final edited form as: Curr Alzheimer Res. 2011 Jun;8(4):393–409. doi: 10.2174/156720511795745401

Figure 6. Localization of mutant proteins of SOD1 in the mitochondria in neurons affected by ALS.

Figure 6

In ALS, mutant SOD1 is localized to inner, outer mitochondrial membranes, intermembrane space and matrix, and induce free radical production and oxidative damage. Impairment of Complex II and IV are associated with ALS.