Fig. 2.

Tnfr1 deficiency rescues abnormalities in Tab1Tab2^DKO. (A and B) TNF receptor-deficient control (Tnfr1^−/−) and epidermal- or intestinal epithelial-specific triple-knockout (Sk-Tab1Tab2^DKO Tnfr1^−/− and In-Tab1Tab2^DKO Tnfr1^−/−) mice at postnatal day 5 (skin) or postnatal day 0 (intestine). Nine (skin) and five (intestine) triple-knockout mice and their littermate mice were analyzed. Representative mice and the intestines are shown. (C) The dorsal skin sections at P5 or cross-sections of intestine at P0 from control and triple-knockout mice were stained with hematoxylin/eosin. (D) Apoptotic cells were detected with TUNEL staining (green). Nuclei were stained by DAPI (blue). Open brackets indicate epidermis. (Scale bars, 40 μm.)