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. 2012 Feb 16;109(9):3197–3198. doi: 10.1073/pnas.1200326109

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Fig. 1. — Properties displayed by vacuoles containing Legionella. (A) Vacuoles containing wild type Legionella deliver the SdhA protein into the cytosol and the PlaA protein into the vacuole lumen. These vacuoles remain intact and infected macrophages do not display enhanced activation of cytosolic surveillance pathways. (B) Vacuoles containing the Δ;sdhA mutant display a loss of membrane integrity and enhanced activation of cytosolic surveillance pathways is observed. (C) Vacuoles containing the Δ;sdhA, Δ;plaA double mutant are stable and macrophages do not show enhanced activation of cytosolic surveillance pathways.