Table 1.
Structure of the NFκB and IκB proteins and the IKK complex.129
| Protein | Amino acid length | Domains |
|---|---|---|
| NF-κB | ||
| p65 (RelA) | 551 | RHD, TAD |
| cRel | 619 | RHD, TAD |
| RelB | 579 | LZ, RHD, TAD |
| NF-κB and IκB | ||
| p100 (p52) | 899 | RHD, 7 ankyrin repeats |
| p105 (p50) | 969 | RHD, 7 ankyrin repeats |
| IκB | ||
| IκBα | 317 | 6 ankyrin repeats |
| IκBβ | 356 | 6 ankyrin repeats |
| IκBγ | 607 | 7 ankyrin repeats |
| IκBε | 361 | 7 ankyrin repeats |
| Bcl3 | 446 | 7 ankyrin repeats |
| IκBζ | 718 | 5 ankyrin repeats |
| IKK complex | ||
| IKK1 (IKKα) | 745 | Kinase, LZ, HLH, NBD |
| IKK2 (IKKβ) | 756 | Kinase, LZ, HLH, NBD |
| NEMO (IKKγ) | 419 | CC1, CC2, LZ, Z |
Abbreviations: CC, coiled-coil domain; HLH, helix-loop-helix; IκB, inhibitor of κB; IKK inhibitory κB kinase; LZ, leucine zipper; NBD, NEMO, NF-κB essential modulator binding domain; NF-κB, nuclear factor κB; RHD, rel homology domain; TAD, transactivation domain; Z, zinc finger.