Table 3.
Association of ARID5B SNP Genotype With Risk of ALL Relapse
SNP ID | Location*(chromosome 10) | ALL Susceptibility |
ALL Relapse |
Risk Allele Frequency† |
||||||
---|---|---|---|---|---|---|---|---|---|---|
Risk Allele | P (White) | P (Hispanic) | Risk Allele | P | HR | 95% CI | White | Hispanic | ||
rs6479778 | 63689077 | T | .0029 | .0296 | T | 8.1× 10−5 | 1.48 | 1.22 to 1.80 | 0.14 | 0.29 |
rs2893881 | 63688672 | C | .001 | .0423 | C | 1.13× 10−4 | 1.45 | 1.20 to 1.75 | 0.14 | 0.30 |
rs4948488 | 63685154 | C | .0043 | .0345 | C | 2.6× 10−4 | 1.41 | 1.18 to 1.69 | 0.16 | 0.41 |
rs2393782 | 63670859 | G | .0883 | .029 | G | .0087 | 1.35 | 1.08 to 1.69 | 0.12 | 0.27 |
rs10821938 | 63724773 | A | 1.47× 10−14 | 2.96× 10−6 | A | .0298 | 1.20 | 1.02 to 1.45 | 0.42 | 0.54 |
rs7923074 | 63723440 | T | 1.5× 10−13 | 4.69× 10−7 | T | .0391 | 1.20 | 1.01 to 1.43 | 0.42 | 0.53 |
rs6479779 | 63695048 | C | .0126 | .0364 | C | .0419 | 1.20 | 1.01 to 1.45 | 0.38 | 0.40 |
rs17215180 | 63688728 | C | .251 | .0181 | C | .0494 | 1.22 | 1.00 to 1.49 | 0.53 | 0.70 |
NOTE. P values < .05 are shown in bold.
Abbreviations: ALL, acute lymphoblastic leukemia; HR, hazard ratio; ID, identification; SNP, single nucleotide polymorphism.
Chromosomal locations are based on hg19.
Allele frequency was determined on the basis of non-ALL controls.