Table 2.
Toxicity
| Toxicity | Treatment |
|||
|---|---|---|---|---|
| BEP (N = 161) |
T-BEP (N = 161) |
|||
| No. of Patients | % | No. of Patients | % | |
| Hematologic toxicity | ||||
| Leucocytes < 1.0 × 10 g/L | 17 | 10.6 | 26 | 16.1 |
| Leucocytopenic fever* | 16 | 10 | 31 | 19.2 |
| Platelets < 25 × 10 g/L | 5 | 3.1 | 5 | 3.1 |
| Nonhematologic toxicity | ||||
| Allergic reaction | ||||
| Grades 1-2† | 15 | 9.3 | 30 | 18.6 |
| Grades 3-4 | 0 | 0 | 9 | 5.5 |
| Fatigue | ||||
| Grades 1-2 | 111 | 69 | 103 | 64 |
| Grades 3-4 | 4 | 2.5 | 12 | 7.5 |
| Stomatitis/mucocitis | ||||
| Grades 1-2 | 57 | 35.4 | 72 | 44.7 |
| Grades 3-4 | 4 | 2.5 | 15 | 9.4 |
| Diarrhea | ||||
| Grades 1-2 | 32 | 19.9 | 56 | 34.8 |
| Grades 3-4 | 3 | 1.9 | 16 | 9.9 |
| Sensory neuropathy | ||||
| Grades 1-2 | 46 | 28.5 | 57 | 35.4 |
| Grades 3-4 | 2 | 1.2 | 0 | 0 |
| Other neurotoxicity | ||||
| Grades 1-2 | 23 | 14.3 | 24 | 14.9 |
| Grades 3-4 | 3 | 1.2 | 1 | 0.6 |
| Nausea | ||||
| Grades 1-2 | 117 | 72.7 | 114 | 70.8 |
| Grades 3-4 | 7 | 4.3 | 11 | 6.8 |
Abbreviations: BEP, bleomycin, etoposide, and cisplatin; T-BEP, paclitaxel–bleomycin, etoposide, and cisplatin.
*
Leucocytes < 2.0 × 10 g/L, temperature > 38°C.
†
Denotes National Cancer Institute Common Toxicity Criteria version 2.0, worst toxicity reported over all cycles.