Table 1.

Demographics and Clinical Characteristics of Patients With ROS1-Positive NSCLC

Demographic or Clinical Characteristic	All Patients (n = 1,073)		ROS1 Positive (n = 18)		ALK Positive (n = 31)		ROS1 Negative (n = 1,055)		P (ROS1 positive v ROS1 negative)
	No.	%	No.	%	No.	%	No.	%
Age, years
Median	62.0		49.8		51.6		62.3		< .001
Range	32-87		32-79		29-73		32-87
Sex
Male	523	49	7	39	17	55	516	49	.480
Female	550	51	11	61	14	45	539	51
Smoking history
Never-smoker	239	22	14	78	13	42	225	21	< .001
Light smoker	62	6	1	6	1	3	61	6
Smoker	695	65	2	11	3	10	693	66
NA	77	7	1	6	14	45	76	7
Ethnicity
Asian	45	4	5	28	2	6	40	4	< .001
Non-Asian	942	88	13	72	18	58	929	88
NA	86	8	0	0	11	35	86	8
Pathology
Adenocarcinoma	694	65	18	100	16	52	676	64	.019
Squamous	200	19	0	0	1	3	200	19
NSCLC, NOS	59	5	0	0	0	0	59	6
Adenosquamous	10	1	0	0	0	0	10	1
Other	38	4	0	0	0	0	38	4
NA	72	7	0	0	14	45	72	7
Stage
IA	218	20	1	6	1	3	217	21	NS
IB	140	13	1	6	1	3	139	13	NS
IIA	44	4	1	6	2	6	43	4	NS
IIB	87	8	0	0	1	3	87	8	NS
IIIA	139	13	2	11	5	16	137	13	NS
IIIB	73	7	2	11	2	6	71	7	NS
IV	327	30	11	61	12	39	316	30	.010
NA	45	4	0	0	7	23	45	4

Abbreviations: NA, not available; NOS, not otherwise specified; NS, not significant; NSCLC, non–small-cell lung cancer.