. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):527–534. doi: 10.1097/MCO.0b013e32834bbac9

Table 1. Reported trait-associated CD36 SNPs.

SNPs are listed based on chromosomal position. Average minor allele frequencies (MAF), Average r² and captured SNPs were generated in TagSNP. “Tag Associated phenotypes” refers to parameters reported to associate with the particular SNP used as a Tag (listed in the Tag SNP column). TagSNP associated trait refers to phenotypes reported to associate with the SNPs in the “Captured SNPs” column. For example, LDL-associated TagSNP rs2151916 is in linkage disequilibrium with the “captured SNP” rs3211816, which was reported to associate with BMI, WC and BMI-dependent insulin sensitivity [49]. Abbreviations: MetS-metabolic syndrome; TAG-triacylglycerol; DHA-dehydroascorbc acid; WC-waist circumference, MI-myocardial infarction. HapMap populations (ASW- African ancestry in Southwest USA; CEU- Utah residents with Northern and Western European ancestry from the CEPH collection; JPT-Japanese in Tokyo, Japan).

Tag SNP	Avg MAF	Avg r²	Captured SNP list by population			tag SNP associated trait	Captured SNP associated trait	Ref.
Tag SNP	Avg MAF	Avg r²	ASW	CEU	JPT	tag SNP associated trait	Captured SNP associated trait	Ref.
rs1761663	0.41	0.93	rs1761663	rs1761663 rs2151916 rs3211816	rs1761663 rs3211816	Left Ventricular Mass, BMI		[43]
rs1984112	0.23	1.00				TAG, FFA, TAG response to DHA		[28, 44]
rs1761667	0.42	1.00				FFA, HDL, monocyte CD36 expression, TAG response to DHA, platelet CD36 expression, plasma a-tocopherol, Macular pigment optical density		[20, 28, 44–47]
rs2151916	0.33	0.95		rs1761663 rs2151916 rs3211816^a	rs2151916	LDL	BMI^a, WC^a, BMI dependent insulin sensitivity^a	[48, 49]
rs9784998	0.15	0.94	rs3173798^b rs9784998	rs3173798 rs3211867^c rs3211883 rs9784998	rs3211867 rs9784998	HDL, BMI, WC, BMI dependent insulin sensitivity, platelet CD36 expression,	MetS^b, Macular Degeneration^b, obesity, platelet CD36 expression^c	[45, 49–52]
rs1334513	0.45	1.00	rs1334513	rs3211909 rs3211913		MetS		[52]
rs1527479	0.38	0.94	rs1527479	rs1049654 rs10499859^d rs1054516^e rs1358337 rs1527479 rs3211842 rs3211849^f rs3211870	rs1049654 rs10499859 rs13438282 rs1527479 rs3211849	Type 2 diabetes, insulin resistance, reduced plasma a-tocopherol	Left Ventricular Mass^d, HDL^d,e,f platelet CD36 expression^d,f	[45, 46, 52–54]
rs1049654	0.39	0.94	rs1049654	rs1049654 rs10499859 rs1054516 rs1358337 rs1527479 rs3211842 rs3211849 rs3211870	rs1049654 rs10499859 rs1527479 rs3211849	HDL, MetS, platelet CD36 expression		[45, 52]
rs3211842	0.46	0.93		rs1049654 rs10499859 rs1054516 rs1358337 rs1527479 rs3211842 rs3211849 rs3211870	rs1054516 rs3211842	HDL, platelet CD36 expression		[45, 52]
rs3211870	0.44	0.93	rs3211870	rs1049654 rs10499859 rs1054516 rs13438282 rs1358337 rs1527479 rs3211842 rs3211849 rs3211870	rs3211870	HDL, platelet CD36 expression		[45, 52]
rs1358337	0.43	0.92	rs1358337	rs1049654 rs10499859 rs1054516 rs13438282 rs1358337 rs1527479 rs3211842 rs3211849 rs3211870	rs1358337	Alzheimer’s disease, HDL, monocyte CD36, platelet CD36		[20, 45, 52, 55]
rs3211883	0.16	0.85		rs3173798 rs3211883 rs9784998	rs3211883	BMI, WC, %BF, platelet CD36 expression		[45, 49]
rs3211909	0.22	1.00		rs3211913 rs1334513		HDL, monocyte and platelet CD36 expression		[20, 52]
rs3211913	0.35	1.00		rs3211909		HDL, monocyte and platelet CD36 expression		[20, 52]
rs3211928	0.39	0.97	rs3211928 rs3211931	rs13230419 rs13246513 rs3173804 rs3211928 rs3211931 rs3211960 rs7755	rs3211928 rs3211931 rs7755	Total Stroke		[56]
rs3211938	0.09	1.00	rs3211938	--	--	Monocyte and Platelet CD36 expression, MetS, HDL		[52]
rs3211956	0.16	0.98		rs1527483 rs3211956	rs1527483 rs3211956	BMI, WC, Acute MI		[49, 57]
rs7755	0.39	0.96	rs7755	rs13230419 rs13246513 rs3173804 rs3211928 rs3211931 rs3211960 rs7755	rs3211928 rs3211931 rs7755	Total cholesterol, Stroke, MetS		[52, 56, 58]
rs1049673	0.36	1.00		rs1049673		TAG response to DHA, FFA in men, MetS		[28, 44, 59]
rs13246513	0.39	0.96		rs13230419^g rs13246513 rs3173804^h rs3211928 rs3211931 rs3211960 rs7755	rs13230419 rs13246513 rs3173804 rs3211960	HDL^h, total stroke^g,h, MetS, plasma luten		[52, 56]